Neuron-specific membrane glycoproteins promoting neurite fasciculation in Aplysia californica.
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چکیده
منابع مشابه
Neuron-specific membrane glycoproteins promoting neurite fasciculation in Aplysia californica
We have generated a library of mouse monoclonal antibodies against membrane proteins of the nervous system of the marine snail Aplysia californica. Two of these antibodies, 4E8 and 3D9, recognize a group of membrane glycoproteins with molecular masses of 100-150 kD. We have called these proteins ap100, from the molecular mass of the most abundant species. Based on Western blots, these proteins ...
متن کاملMembrane glycoproteins involved in neurite fasciculation
Lectin affinity chromatography combined with mAb production was used to identify chick neural cell surface molecules related to L1 antigen, a mouse neural glycoprotein implicated in cell-cell adhesion (Rathjen, F. G., and M. Schachner, 1984, EMBO (Eur. Mol. Biol. Organ.) J., 3:1-10). A glycoprotein, G4 antigen, isolated by mAb G4 from adult chick brain is described which comprises a major 135-k...
متن کاملAxonal Transport of Newly Synthesized Glycoproteins in a Single Identified Neuron of Aplysia Californica
Increasing amounts of glycoprotein synthesized from L-[ 3H]fucose injected into the cell body of R2, an identified Aplysia neuron, were found in the right pleuroabdominal connective . Autoradiography revealed that the glycoproteins were localized in the axon of R2. Glycoproteins appearing in the axon presumably were synthesized in the cell body, since no significant incorporation was observed w...
متن کاملAxonal Transport of Newly Synthesized Glycoproteins in a Single Identified Neuron of Aplysia Californica
Increasing amounts of glycoprotein synthesized from L-[(3)H]fucose injected into the cell body of R2, an identified Aplysia neuron, were found in the right pleuro-abdominal connective. Autoradiography revealed that the glycoproteins were localized in the axon of R2. Glycoproteins appearing in the axon presumably were synthesized in the cell body, since no significant incorporation was observed ...
متن کاملSynthesis of Glycoproteins in a Single Identified Neuron of Aplysia Californica
Incorporation of L-[(3)H]fucose into glycoproteins was studied in R2, the giant neuron in the abdominal ganglion of Aplysia. [(3)H]fucose injected directly into the cell body of R2 was readily incorporated into glycoproteins which, as shown by autoradiography, were confined almost entirely to the injected neuron. Within 4 h after injection, 67% of the radioactivity in R2 had been incorporated i...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1990
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.111.6.2637